Can Blood Oxygen Level-Dependent Imaging Depict the Ischemic Penumbra?
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منابع مشابه
Oxygen imaging by MRI: can blood oxygen level-dependent imaging depict the ischemic penumbra?
M apping the ischemic penumbra (ie, the neurophysio-logically silent but still viable ischemic tissue) is increasingly part of routine assessment in suspected acute stroke, although whether this approach is cost-effective is still unclear. 1,2 The penumbra is characterized by both low cerebral blood flow (CBF; Ͻ20 mL ⅐ 100 g Ϫ1 ⅐ min Ϫ1) and elevated oxygen extraction fraction (OEF). 3 The latt...
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fMRI ASSESSMENT OF ISCHEMIC STROKE IN HUMANS By Rui Yuan Cerebral ischemia, or brain ischemia is a kind of stroke where the blood flow is insufficient to the metabolic demand of brain. The lack of oxygen supply will directly lead to the death of brain tissue. There are two major injury regions: the infarct and penumbra. Mostly, since the infarct regions became dead tissues rapidly after stroke,...
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Within the ischemic penumbra, blood flow is sufficiently reduced that it results in hypoxia severe enough to arrest physiological function. Nevertheless, it has been shown that cells present within this region can be rescued and resuscitated by restoring perfusion and through other protective therapies. Thus, the early detection of the ischemic penumbra can be exploited to improve outcomes afte...
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BACKGROUND Identifying the ischemic penumbra in acute stroke subjects is important for the clinical decision making process. The aim of this study was to use resting-state functional magnetic resonance singal (fMRI) to investigate the change in the amplitude of low-frequency fluctuations (ALFF) of these subjects in three different subsections of acute stroke regions: the infarct core tissue, th...
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BACKGROUND AND PURPOSE Penumbral biomarkers promise to individualize treatment windows in acute ischemic stroke. We used a novel magnetic resonance imaging approach that measures oxygen metabolic index (OMI), a parameter closely related to positron emission tomography-derived cerebral metabolic rate of oxygen utilization (CMRO2), to derive a pair of ischemic thresholds: (1) an irreversible-inju...
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